Thesis Titles

Cycle XXXVII (AFTI = Drug Area and Innovative Treatments; DE = Doctor Europeus)

1) Title: “Identification of new molecular targets for the development of innovative drugs: PGF2-NO donor for the treatment of retinal disease and new characterization of the molecular pharmacology of the atypical chemokine receptor GPR182 (ACKR5) in recombinant cell lines”. Candidate: Dr. Silvia Marri. SSD: BIOS-11/A; AFTI + DE

2) Title: “Characterization of Tryptophan 2,3-dioxygenase in human melanoma cell lines and endothelial cells as a new therapeutic target”. Candidate: Dr. Marta Cecchi. SSD: BIOS-11/A; AFTI + DE

3) Title: “Design, synthesis and evaluation of small molecules as modulators of ion channels and enzymes”. Candidate: Dr. Alessio Gabellini. SSD: CHEM-07/A; AFTI

4) Title: “Computational approaches in drug discovery: strategies to address polypharmacology and the synthesis/optimization of lead compounds”. Candidate: Dr. Niccolò Paoletti. SSD: CHEM-07/A; AFTI

5) Title: “Efficacy and safety of oral mammalian target of rapamycin (mTOR) inhibitors in children and adolescents with epileptogenic hyperactivating constitutional and somatic mutations in the mTOR pathway genes”. Candidate: Dr. Alessandra Boncristiano. SSD: MEDS-20/B; AFTI

6) Title: “Characterization of a novel Glucocerebrosidase pharmacological chaperone in cellular and animal models of alpha-synuclein neurotoxicity”. Candidate: Dr. Antonino Iurato La Rocca. SSD: BIOS-11/A; AFTI

7) Title: “Different immunophenotypes and cytokine profiles in non-systemic Juvenile Idiopathic Arthritis (JIA): potential fingerprints for predicting disease course and flare and guiding therapeutic decisions”. Candidate: Dr. Ilaria Maccora. SSD: MEDS-20/A; AFTI

8) Title: “Phenotypic and genetic spectrum of ATP6V1A encephalopathy: a disorder of lysosomal homeostasis”. Candidate: Dr. Davide Mei. SSD: MEDS-20/A; AFTI

9) Title: “Novel pharmacological options for cardiac hypertrophy: a functional study in human myocardium”. Candidate: Dr. Monica Musumeci. SSD: BIOS-11/A; AFTI

10) Title: “From the impact of microbiota to the efficacy of phytotherapy: researching novel therapeutic approaches for treating visceral hypersensitivity in colon organoid-based models”. Candidate: Dr. Francesco Margiotta. SSD: BIOS-11/A; AFTI

11) Title: “Role of coronavirus Envelope viroporin on human cell homeostasis and dysfunction”. Candidate: Dr. Andrea Ninu. SSD: BIOS-11/A; AFTI

12) Title: “Ulvan from Ulva lactuca L.: a multitarget approach for chemical characterization combined with in vitro tests on human gut microbiota”. Candidate: Dr. Beatrice Zonfrillo. SSD: CHEM-07/B; AFTI + DE

Cycle XXXVI (AFTI = Drug Area and Innovative Treatments; DE = Doctor Europeus)

1) Title: “Exploring novel pathogenetic mechanisms and potential therapeutic targets for developmental and epileptic encephalopathy caused by lysosomal and autophagic dysfunction”. Candidate: Dr. Antonio Falace. SSD: MED/39; AFTI

2) Title: “Unveiling the neuroprotective role of IFN-γ in oxaliplatin-induced neurotoxicity: Insights from transcriptomic profile analysis of neuropathic mice”. Candidate: Dr. Valentina Ferrara. SSD: BIO/14; AFTI

3) Title: “A multi-level system to improve knowledge of pharmacological therapy among women of childbearing age, during pregnancy, and postpartum using serious gaming applications”. Candidate: Dr. Roberto Bonaiuti. SSD: BIO/14; AFTI

4) Title: “Acute and chronic effects of cannabinoids in experimental models of cerebral ischemia and epilepsy in vitro”. Candidate: Dr. Costanza Mazzantini. SSD: BIO/14; AFTI

5) Title: “Effects of diets, drugs, and natural compounds on the prevention of colon carcinogenesis: the role of intestinal microbiome”. Candidate: Dr. Sofia Chioccioli. SSD: BIO/14; AFTI

6) Title: “Carbonic anhydrase inhibitors: design, synthesis and bioevaluation of new multi-target agents”. Candidate: Dr. Simone Giovannuzzi. SSD: CHIM/08; AFTI

7) Title: “Small molecular probes as modulators of targets involved in cancer and neurodegenerative diseases”. Candidate: Dr. Erica Vigiani. SSD: CHIM/08; AFTI

Cycle XXXV (AFTI = Drug Area and Innovative Treatments; DE = Doctor Europeus)

1) Title: “Single nuclei transcriptome analysis of focal malformations of cortical development”. Candidate: Dr. Clara Tuccari Di San Carlo. SSD: MED/39; AFTI

2) Title: “Histamine H3 receptor (H3R) antagonist-Nitric Oxide (NO) donor hybrid compounds as a new therapeutic strategy for the treatment of glaucoma and retinal neuroprotection”. Candidate: Dr. Silvia Sgambellone. SSD: BIO/14; AFTI

3) Title: “Quality by Design application to the development of analytical procedures in the pharmaceutical and nutraceutical field for the determination of drugs and bioactive molecules”. Candidate: Dr. Luca Marzullo. SSD: CHIM/01; AFTI

4) Title: “Design, synthesis and properties of novel peptidomimetics for cosmeceutical applications”. Candidate: Dr. Patrycia LEDWOŃ. SSD: CHIM/08; AFTI (Co-tutorship 50% with University of Wroclaw, Poland)

5) Title: “Application of nanotechnologies for the development of innovative drug delivery systems aimed at improving therapeutic efficacy”. Candidate: Dr. Giulia Nerli. SSD: CHIM/09; SF + DE

6) Title: “Application of advanced mass spectrometry techniques for the development of analytical methods to study molecules of pharmaceutical and biological interest”. Candidate: Dr. Marco Pallecchi. SSD: CHIM/08; SF + DE

7) Title: “The promising future of microalgae: new pharmacological applications for human health”. Candidate: Dr. Mario D’Ambrosio. SSD: BIO/14; AFTI