Titoli delle Tesi

Ciclo XXXVII (AFTI = Area del farmaco e Trattamenti Inovativi; DE = Doctor Europeus)

1) Title: “Identification of new molecular targets for the development of innovative drugs: PGF2-NO donor for the treatment of retinal disease and new characterization of the molecular pharmacology of the atypical chemokine receptor GPR182 (ACKR5) in recombinant cell lines”. Candidata: Dr.ssa Silvia Marri. SSD: BIOS-11/A; AFTI + DE

2) Title: “Characterization of Tryptophan 2,3-dioxygenase in human melanoma cell lines and endothelial cells as a new therapeutic target”. Candidata: Dr.ssa Marta Cecchi. SSD: BIOS-11/A; AFTI + DE

3) Title: “Design, synthesis and evaluation of small molecules as modulators of ion channels and enzymes”. Candidato: Dr. Alessio Gabellini. SSD: CHEM-07/A; AFTI

4) Title: “Computational approaches in drug discovery: strategies to address polypharmacology and the synthesis/optimization of lead compounds: Candidato: Dr. Niccolò Paoletti. SSD:CHEM-07/A; AFTI

5) Title: “Efficacy and safety of oral mammalian target of rapamycin (mTOR) inhibitors in children and adolescents with epileptogenic hyperactivating constitutional and somatic mutations in the mTOR pathway genes”. Candidata Dr.ssa Alessandra Boncristiano. SSD: MEDS-20/B; AFTI

6) Title: “Characterization of a novel Glucocerebrosidase pharmacological chaperone in cellular and animal models of alpha-synuclein neurotoxicity”. Candidato Dr. Antonino Iurato La Rocca. SSD: BIOS-11/A; AFTI

7) Title: “Different immunophenotypes and cytokine profiles in non-systemic Juvenile Idiopathic Arthritis (JIA): potential fingerprints for predicting disease course and flare and driving therapeutic decisions”. Candidata Dr.ssa Ilaria Maccora. SSD: MEDS-20/A; AFTI

8) Title: “Phenotypic and genetic spectrum of ATP6V1A encephalophaty: a disorder of lysosomal homeostasis”. Candidato Dr. Davide Mei. SSD: MEDS-20/A; AFTI

9) Title: “Novel pharmacological options for cardiac hypertrophy: a functional study in human myocardium”. Candidata Dr.ssa Monica Musumeci. SSD: BIOS-11/A; AFTI

10) Title: “From the impact of microbiota to the efficacy of phytotherapy: researching novel therapeutic approaches for treating visceral hypersensitivity in colon organoid-based models”. Candidato Dr. Margiotta Francesco. SSD: BIOS-11/A; AFTI

11) Title: “Role of coronavirus Envelope viroporin on human cell homeostasis and dysfunction”. Candidato Dr. Andrea Ninu. SSD: BIOS-11/A; AFTI

12) Title: “Ulvan from Ulva lactuca L.: a multitarget approachfor chemical characterization combined with in vitro tests on human gut microbiota.”. Candidata Dr.ssa Beatrice Zonfrillo. SSD: CHEM-07/B; AFTI + DE

Ciclo XXXVI (AFTI = Area del farmaco e Trattamenti Inovativi; DE = Doctor Europeus)

1) Title: “Exploring novel pathogenetic mechanism of and potential therapeutic targets for developmental and epileptic encephalopathy caused by lysosomal and autophagic dysfunction.”. Candidato Dr. Antonio Falace. SSD: MED/39; AFTI

2) Title: “Unveiling the neuroprotective role of IFN-y in oxaliplatin-induced neurotoxicity: Insights from transcriptomic profile analysis of neuropathic mice”. Candidata Dr.ssa Valentina Ferrara. SSD: BIO/14; AFTI

3) Title: “Un sistema multilivello per migliorare la conoscenza della terapia farmacologica tra le donne in età fertile, nella gravidanza e nel post-parto usando applicazioni di serious gaming”. Candidato Dr. Roberto Bonaiuti. SSD: BIO/14; AFTI

4) Title: “Acute and chronic effects of cannabinoids in experimental models of cerebral ischemia and epilepsy in vitro”. Candidata Dr.ssa Costanza Mazzantini. SSD: BIO/14; AFTI

5) Title: “Effects of diets, drugs, and natural compounds on the prevention of colon carcinogenesis: the role of intestinal microbiome”. Candidata Dr.ssa Sofia Chioccioli. SSD: BIO/14; AFTI

6) Title: “Carbonic anhydrase inhibitors: design, synthesis and bioevaluation of new multi- target agents”. Candidato Dr. Simone Giovannuzzi. SSD: CHIM/08; AFTI

7) Title: “Small molecular probes as modulators of targets involved in cancer and neurodegenerative diseases”. Candidata Dr.ssa Erica Vigiani. SSD: CHIM/08; AFTI

Ciclo XXXV (AFTI = Area del farmaco e Trattamenti Inovativi; DE = Doctor Europeus)

1) Title: “Single nuclei transcriptome analysis of focal malformations of cortical development.”. Candidata Dr.ssa Clara Tuccari Di San Carlo. SSD: MED/39; AFTI

2) Title: “Histamine H3 receptor (H3R) antagonist-Nitric Oxide (NO) donor hybrid compounds as a new therapeutic strategy for the treatment of glaucoma and retinal neuroprotection.”. Candidata Dr.ssa Silvia Sgambellone. SSD: BIO/14; AFTI

3) Title: “Quality by Design application to the development of analytical procedures in the pharmaceutical and nutraceutical field for the determination of drugs and bioactive molecules.”. Candidato Dr. Luca Marzullo. SSD: CHIM/01; AFTI

4) Title: “Design, synthesis and properties of novel peptidomimetics for cosmeceutical applications.”. Candidata Dr.ssa Patrycia LEDWOŃ. SSD: CHIM/08; AFTI (Co-tutela 50% con 'Università di Wroclaw, Polonia)

5) Title: “Application of Nanotechnologies for the Development of Innovative Drug Delivery Systems Aimed at Improving Therapeutic Efficacy”. Candidata Dr.ssa Nerli Giulia. SSD: CHIM/09; SF + DE

6) Title: “Application of advanced mass spectrometry techniques for the development of analytical methods to study molecules of pharmaceutical and biological interest”. Candidato Dr. Marco Pallecchi. SSD: CHIM/08; SF + DE

7) Title: “The promising future of microalgae: new pharmacological applications for human health”. Candidato Dr. D’Ambrosio Mario. SSD: BIO/14; AFTI